The l carnitine treated centenarians, compared with the placebo group, showed significant improvements in total fat mass, total muscle mass, and plasma concentrations of total carnitine. Significant differences were also found in physical fatigue and mental fatigue. Our study indicates that oral administration of l carnitine produces a reduction of total fat mass, increases total muscular mass, and facilitates an increased capacity for physical and cognitive activity by reducing fatigue and improving cognitive functions. L carnitine administration in elderly subjects with rapid muscle fatigue: effect on body composition, lipid profile and fatigue.
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